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Ketamine is an anesthetic that is used to induce and maintain anesthesia. It causes dissociative anesthesia, a trance-like state that relieves pain while also delivering sleepiness and amnesia. Preserved breathing and airway reflexes, accelerated heart activity with elevated blood pressure, and moderate bronchodilation are all characteristics of ketamine anesthesia.
Ketamine is a promising medication for pain and treatment-resistant depression at lower, sub-anesthetic doses. However, the antidepressant effect of ketamine wears off over time, and the implications of chronic usage have not been thoroughly investigated.
Raised blood pressure and nausea are common psychiatric adverse effects. Regular users of high doses of ketamine for recreational purposes are prone to liver and urinary damage. Ketamine is an NMDA receptor antagonist, which explains most of its effects except for the antidepressive effect, which has been the subject of considerable research and discussion.
Ketamine was originally produced in 1962, and it received FDA approval in 1970. During the Vietnam War, it was commonly used on dogs and horses, as well as for surgical anaesthetic. Ketamine is also used recreationally, both in powder and liquid form, and is known as “Special K” because of its hallucinogenic and dissociative properties. It is listed as an essential medicine by the World Health Organization. It can be purchased as a generic drug.